Health Condition 1: null- Carcinoma esophagus patients undergoing neoadjuvant chemoradiotherapy
Conditions
Interventions
Intervention1: Histopathology: post esophagestomy histopatholgy of specimen
Control Intervention1: PET/CT: PET/CT in assessment of metabolic response of neoadjuvant chemoradiotherapy in patients with
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 2. Squamous cell carcinoma 3. Good performance status (Eastern Cooperative Oncology Group [ECOG] grades 0, 1 and 2) 4. Contrast enhanced computerized tomographic (CECT) scan suggesting a potentially resectable lesion. The features of resectability assessed on CECT scan will include - no evidence of infiltration of mediastinal structures such as the aorta (angle of contact 5. No evidence of distant metastasis on CECT.
Exclusion criteria
Exclusion criteria: 1. Comorbid conditions which would preclude esophagectomy Poor performance status (ECOG > 2) American Society of Anesthesiologists class IV 2. Metastatic disease detected on evaluation 3. Involvement of mediastinal structures 4. Carcinoma involving cervical esophagus 5. Previous radiotherapy or chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the accuracy of 18 F-FDG PET in the prediction of tumor response to neoadjuvant therapy in patients with esophageal and gastroesophageal junction cancers.Timepoint: PET/CT before and after neoadjuvant chemoradiotherapy and results are compared to Histopatholgy | — |
Secondary
| Measure | Time frame |
|---|---|
| comparing metabolic response between Ct and PET/CTTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactVISHNU RAVELLA
AIIMS
Outcome results
None listed