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Effect of continuous intravenous infusion of dexmedetomidine and esmolol on patients hemodynamics and pain after operation in laproscopic urological surgeries.

Effect of continuous infusion of dexmedetomidine and esmolol on hemodynamic attenuation and post operative analgesic requirement in patients undergoing laproscopic urological surgeries - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2014/01/004268
Enrollment
90
Registered
2014-01-01
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dexmedetomidine infusion.: Induction with 1ug/kg over 15 mins, then 0.5ug/kg/hr, intravenously during intraoperative period. Control Intervention1: Esmolol infusion: Induction with 1mg/

Sponsors

SGPGI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing laparoscopic urological procedures. Surgeries to be included: Laparoscopic donor nephrectomy, lap simple nephrectomies, and lap pyeloplasty.

Exclusion criteria

Exclusion criteria: 1.Consent not given. 2.ASA physical status III and more, 3.History of hepatic, renal, or cardiac failure, organ transplant, 4.History of diabetes, morbid obesity (body mass index > 40), 5.Chronic use of opioids or ß adrenergic receptor antagonists, 6.Known asthma or reactive airway disease, 7.Severe mental impairment, 8.Allergy to any of two drugs, or 9.Inability to comprehend pain assessment.

Design outcomes

Primary

MeasureTime frame
To compare the hemodynamic effects of dexmedetomidine and esmolol infusions, To compare postoperative requirement of opioids in both groups.Timepoint: During intraoperative period. 24 hrs postoperatively—

Secondary

MeasureTime frame
To study the occurrence of side effects with use of these drugs.Timepoint: Intraoperative and 24hrs postoperatively;To compare nausea and vomiting and requirement of antiemetic in post operative period.Timepoint: Immediate postopaerative period till 24hrs postoperatively;To compare the time of awakening and extubation after stopping anesthetic agent Timepoint: Immediately after operation—

Countries

India

Contacts

Public ContactDr Divya Srivastava

Sanjay Gandhi Post Graduate Institute, Lucknow.

drsandeepsahu@yahoo.co.in8004904598

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026