Health Condition 1: null- ASA I patients undergoing elective surgical procedures under general anesthesia
Conditions
Interventions
Intervention1: Gabapentin: 800mg orally 2 hrs before induction of anesthesia
Intervention2: Gabapentin plus Fentanyl: Gabapentin 800 mg orally 2 hrs before and Fentanyl 2 microgram/kg Intravenous 5 mi
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Admitted for any elective non-cardiac surgery under general anesthesia with endotracheal intubation 2. ASA I
Exclusion criteria
Exclusion criteria: 1. Patients with comorbid illnesses such as hypertension, diabetes mellitus, ischemic heart disease 2. Patients on medications such as beta-blockers, calcium channel blockers and vasodilators 3. Patients with predicted difficulty in intubation, those who required more than one attempt at laryngoscopy and those in whom the duration of laryngoscopy exceeded 30 seconds 4. Patients having allergies to the drugs being administered during the course of the study, and those patients taking antacids and Cimetidine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Compare the effects of a single pre-operative oral dose of 800 mg Gabapentin with 2 μg/kg iv Fentanyl on the hemodynamic response to laryngoscopy & endotracheal intubation 2. To observe if co-administering the two is of added benefit over Fentanyl aloneTimepoint: Hemodynamic responses in the first 10 minutes following laryngoscopy and endotracheal intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Any adverse effects from administration of gabapentin such as dizziness, somnolence, nausea and vomitingTimepoint: 1. At arrival in the pre-operative room 2. In the post-anesthesia care unit every half-an-hr until discharge | — |
Countries
India
Contacts
Public ContactSatyen Parida
JIPMER, Puducherry
Outcome results
None listed