FindTrial
Sign In

Role of endometrial injury in the success of IVF in patients with failed implantation in previous IVF cycles and its genetic basis.

Impact of local endometrial injury (LEI) on the outcome of IVF cycle with previous failed implantation: Exploring the Genome wide transcriptomic basis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/12/004206
Enrollment
40
Registered
2013-12-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- healthy and with failed implantation in previous IVF cycle.

Interventions

Intervention1: Local Endometrium Injury: Patients with unexplained, tubal factor or husband factor infertility having good ovarian reserve will be included in this study. Endometrial scratching will b

Sponsors

All India Institute of Medical Sciences AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women less than 38 years old. 2. Women who have >1 previous failed IVF-ET cycles. 3. Women with good ovarian reserve (AFC >8, AMH 2-6 ng/ml, FSH level 4. No uterine manipulation within last 3 months (e.g. hysteroscopy, myomectomy etc) 5. Women willing to participate in the trial.

Exclusion criteria

Exclusion criteria: 1. Women more than 38 years old with confounding factors(eg Poor ovarian reserve) 2. Women with Grade III & IV Endometriosis. 3. Women with history of septal resection, adhesiolysis &abnormal uterine cavity. 4. Women with possible causes for failure of implantation such as diabetes mellitus, hypertension, autoimmune diseases.. 5. Women not willing to participate in the trial.

Design outcomes

Primary

MeasureTime frame
1) Implantation rate (Time frame; 15-20 days of embryo transfer, serum beta hCG level) Implantation rate will be calculated as a) Number of patients with positive Serum beta hCG on Day 16 of ET b) Number of gestational sacs as seen on transvaginal sonography divided by the number of embryos transferred. 2) Clinical pregnancy rate (Time frame; 8-10 weeks, appearance of cardiac activity) 3) Genomic wide Transcriptomic basis Timepoint: 1) Implantation rate (Time frame; 15-20 days of embryo transfer, serum beta hCG level) Implantation rate will be calculated as a) Number of patients with positive Serum beta hCG on Day 16 of ET b) Number of gestational sacs as seen on transvaginal sonography divided by the number of embryos transferred. 2) Clinical pregnancy rate (Time frame; 8-10 weeks, appearance of cardiac activity) 3) Genomic wide Transcriptomic basis—

Secondary

MeasureTime frame
1. Pregnancy rate/ ongoing pregnancy rate. (Time frame; till 12 weeks of gestation) 2. Miscarriage Rate (Time frame: till 12 weeks of gestation) 3. Endometrial thickness during stimulation (Time frame: during stimulation cycle designated as safety issue: No Timepoint: 1. Pregnancy rate/ ongoing pregnancy rate. (Time frame; till 12 weeks of gestation) 2. Miscarriage Rate (Time frame: till 12 weeks of gestation) 3. Endometrial thickness during stimulation (Time frame: during stimulation cycle designated as safety issue: No—

Countries

India

Contacts

Public ContactDr Neeta Singh

AIIMS

drneetasingh@yahoo.com919868397311

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026