FindTrial
Sign In

Comparison of analgesic action of two doses of dexmedetomidine, when used in addition to bupivacaine, in femoral nerve block given to reduce post operative pain after total knee replacement surgery

EFFECT OF DEXMEDETOMIDINE AS AN ADJUVANT TO BUPIVACAINE IN FEMORAL NERVE BLOCK FOR PERIOPERATIVE ANALGESIA IN PATIENTS UNDERGOING TOTAL KNEE REPLACEMENT ARTHROPLASTY UNDER SUBARACHNOID BLOCK - A DOSE RESPONSE STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/11/004168
Enrollment
60
Registered
2013-11-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- American Society of Anesthesiologists Physical status classes 1, 2 Health Condition 2: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: femoral nerve block: nerve stimulator guided femoral nerve block is used for post operative analgesia in total knee replacement Control Intervention1: dexmedetomidine: Dexmedetomidine i

Sponsors

All India Institute of Medical Sciences
Lead Sponsor
All India Institute of Medical Sciences
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1, 2 patients undergoing unilateral primary total knee replacement arthroplasty

Exclusion criteria

Exclusion criteria: ASA 3,4, bilateral, revision TKR,focal neurological deficits, pre existing peripheral neuropathy,uncontrolled diabetes mellitus,coagulation disorders

Design outcomes

Primary

MeasureTime frame
Quality of post operative analgesia as assessed by, 1) VAS (0-10 scale; 0-no pain; 10-worst possible pain) â?¢ pain at rest at 0, 4, 8, 12, 24, 48 hours after surgery â?¢ pain at motion (knee flexion) at 12, 24, 48 hours after surgery 2) Post operative opioid consumption: Total dose of PCA morphine consumed, dose of rescue analgesia used. 3) Duration of analgesia: Time to first use of patient controlled analgesia Timepoint: Quality of post operative analgesia as assessed by, 1) VAS (0-10 scale; 0-no pain; 10-worst possible pain) â?¢ pain at rest at 0, 4, 8, 12, 24, 48 hours after surgery â?¢ pain at motion (knee flexion) at 12, 24, 48 hours after surgery 2) Post operative opioid consumption: Total dose of PCA morphine consumed, dose of rescue analgesia used. 3) Duration of analgesia: Time to first use of patient controlled analgesia—

Secondary

MeasureTime frame
Adverse effects of dexmedetomidine in peripheral nerve block such as nausea, vomiting, pruritus, sedation, hypotension, bradycardia, neuropathy in the perioperative period will be recordedTimepoint: Adverse effects of dexmedetomidine in peripheral nerve block such as nausea, vomiting, pruritus, sedation, hypotension, bradycardia, neuropathy in the perioperative period will be recorded—

Countries

India

Contacts

Public ContactProf Lokesh Kashyap

All India Institute of Medical Sciences

lokeshkashyap@yahoo.com9868397821

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026