Health Condition 1: null- AEDs withdrawal after pediatric epilepsy surgery
Conditions
Interventions
Intervention1: Early AEDs Withdraw: withdrawing of AEDs will be started from 6 months after surgery.
Control Intervention1: Late AEDs Withdrawal: Reduction of AEDs will be started at 12 months after s
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients who underwent for pediatric epilepsy surgery. 2. Age less than and equal to 18 years. 3. Both the physician, parents And patients, if capable will agree with randomization for participation. 4. Postoperative seizure freedom achieved. 5. Agree to follow-up.
Exclusion criteria
Exclusion criteria: 1) Age greater than 18 years. 2) The treating physician/patient will not agree to discontinue all AEDs within given time frame. 3) Disagree to tapering of AEDs. 4) EEG abnormal except in persons who have undergone hemispherotomy. 5) All Patients who will not give consent for participation and not agree for follow-up. 6) All patients whose treating physician or parents decided to taper their drug treatment despite continuing postoperative seizures, including auras.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome will be measured for seizure recurrence and seizure outcome during or after AEDs withdrawal by ILAE (International League Against Epilepsy)/ Engel scale in both groups and compare the neuropsychological measures between the two withdrawal group at preoperatively (p1), post-operatively (p2) 12 months and 18 months (p3)Timepoint: 6 monthly follow-up and up-to 60 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome will be measure the quality of life, behavior and cognition during and after AEDs withdrawal which affect the seizure outcome.Timepoint: 6 monthly follow-up upto 60 months | — |
Countries
India
Contacts
Public ContactRekha Dwivedi
All India Institute of Medical Sciences
Outcome results
None listed