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This is study to compare efficacy of two beta blockers, propanolol and carvedilol combined with endoscopic therapy for reduction of pressure in veins draining blood from liver to heart and risk of rebleeding in patients with first episode of bleed from dilated esophgeal blood vessels

Open Label Randomized trial of Endoscopic variceal ligation and Carvedilol Vs Endoscopic variceal ligation and Propanolol on hepatic vein pressure gradient reduction at 1 month in patients with first episode of esophageal varix bleed

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/10/004119
Enrollment
100
Registered
2013-10-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic liver disease patients presenting with first episode of variceal bleeding

Interventions

Intervention1: propanolol, endoscopic variceal ligation: one groups of patients will be given propranolol tablets orally started at a dose of 40 mg per day and increased every 3-5 days in increments o

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Chronic liver disease patients presenting with first episode of variceal bleeding and consenting for the study

Exclusion criteria

Exclusion criteria: 1. Failure to give consent to participate in the study 2. Previous medical, surgical or endoscopic treatment for portal hypertension. 3. Child-Pugh score >9 4. Neoplastic disease of any site 5. Splenic or portal vein thrombosis 6. Pregnancy 7. Contraindication to beta-blockers (atrioventricular block, sinus bradycardia with heart rate 8. Renal failure 9. Bleeding other than esophageal varix 10. Inability to come for follow up

Design outcomes

Primary

MeasureTime frame
Reduction in HVPGTimepoint: at 28-30 days after starting combined therapy—

Secondary

MeasureTime frame
variceal rebleedTimepoint: At 1 month—

Countries

India

Contacts

Public ContactDr Ramakant Rawat

All India Institute of Medical Sciences

ansaraya@yahoo.com09868397203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 12, 2026