Health Condition 1: null- Nephrotic Syndrome
Conditions
Interventions
Intervention1: Mycophenolate mofetil: Mycophenolate mofetil 1200 mg/m2 per day along with tapering doses of alternate day prednisolone, during a 12 month period.
Control Intervention1: levamisole: Lev
Sponsors
Nilratan Sircar Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children between 2years and16 years with FRNS with or without steroid dependency. Estimated glomerular filtration rate (eGFR) >80 ml/min per 1.73 m2. Children in remission at study entry (trace or nil proteinuria, as determined by the dipstick test or No previous use of any steroid sparing agent. Informed cosent.
Exclusion criteria
Exclusion criteria: Patients with severe leucopenia (leucocytes less than 3.0Ã? 1000 cells/mm3), severe anemia (haemoglobin less than 8.9 g/dl) or any active infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of relapsesTimepoint: number of relapses at 3,6,9 and 12 month. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to first relapse on steroid sparing treatment(mo) 2. Cumulative steroid dose (mg/kg/yr) 3. Sustained remission 4. Treatment Failure 5. No. of children off steroid at 12 mo. Timepoint: During 12 months period | — |
Countries
India
Contacts
Public ContactBiswanath Basu
NRS Medical College and Hospital
Outcome results
None listed