Health Condition 1: null- acute seizures
Conditions
Interventions
Intervention1: Sodium Valproate: 20 mg /kg loading dose I/V followed by 20 mg / kg/ day maintainance dose in two divided doses for 1 day
Control Intervention1: Phenytoin Sodium: 20 mg/kg/ loading dose
Sponsors
Department of PediatricsGovt Multispeciality hospital Sector Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Presenting with either of following : A clinical features of Motor seizures (generalized or focal ) in active stage at Pediatric Emergency , Patients with acute repetitive seizures ( two or more episodes of seizures in last 12 hours.
Exclusion criteria
Exclusion criteria: 1. 12 years 2. already on antiepileptic drugs 3. children with head trauma 4. very sick child with shock or impending respiratory failure. 5. Known hypersensitive to phenytoin/ Valproate 6. Known liver disease or clinically icteric.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure control and recurrences of seizure for 24 hour period between the two groups Timepoint: Seizure control and recurrences of seizure for 24 hour period between the two groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. time taken to control seizures. 2. variation in cardiorespiratory parameters. 3. time to regain consciousness 4. any adverse effectsTimepoint: vital monitoring at admission, 15 min, 30 min, 1 hr, 6hr, 12 hr and 24 hr. | — |
Countries
India
Contacts
Public ContactDr Ajeshwar Mahant
Govt Multispeciality hospital, sector 16
Outcome results
None listed