Health Condition 1: null- coronary angiography proven stable patients of coronary artery disease
Conditions
Interventions
Intervention1: drug trial
Esomeprazole, Pantoprazole, Rabeprazole.: Esomeprazole 20 mg BD per oral for 1 month
Pantoprazole 40 mg BD per oral for 1 month
Rabeprazole 20 mg BD per oral for 1 month
Cont
Sponsors
Postgraduate Institute of Medical Education and Research Chandigarh
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: • Age â?? 25- 70 years ( both male and female) • Angiography proven stable cases of CAD who are on antiplatelet therapy i.e. Aspirin and Clopidogrel but not taking any Proton Pump Inhibitor (PPI).
Exclusion criteria
Exclusion criteria: • Acute Coronary Syndrome (ACS) • Known CAD Patients who are on antiplatelets (Aspirin & Clopidogrel) and already taking any PPI • Patients with thrombocytopenia (platelet count • Active pathological bleeding or a history of hereditary or acquired Bleeding disorder • Peptic ulcer disease • Patient on oral anticoagulants • Liver disease • Anaemia (haemoglobin • Pregnancy • Chronic Kidney Disease (CKD) (Creatinine > 2.5 mg/dl)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in platelet aggregation with each Proton Pump Inhibitor before and after their introduction in Coronay Artery Disease patients.Timepoint: 4 WEEKS | — |
Secondary
| Measure | Time frame |
|---|---|
| not applicableTimepoint: 4 weeks | — |
Countries
India
Contacts
Public Contactumesh Kumar
Postgraduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed