Health Condition 1: null- Idiopathic Membranous glomerulonephritis
Conditions
Interventions
Intervention1: Cyclophosphamide, Tacrolimus: Cyclophosphamide with steroids versus Tacrolimus with steroids in Idiopathic Membranous Glomerulonephritis
Intervention2: Cyclophoshamide: Intravenous meth
Sponsors
PGIMER
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Biopsy proven idiopathic membranous nephropathy 2. Nephrotic syndrome with proteinuria ( >4 gm/day) or >=2.0 gm/day along with serum albumin 3. At least 6 months on ACEi or ARBs treatment or anyone with severe complicated nephrotic syndrome 4. Age 18-60 yrs with informed consent
Exclusion criteria
Exclusion criteria: 1. Serum creatinine >2.5mg/dl 2. Patients with abnormal liver function tests and diabetes mellitus 3. Active infection 4. Patient with prior therapy with steroids, cyclophosphamide, sirolimus, CSA, MMF, azathioprine and rituximab. 5. Patients with secondary cause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients achieving complete remission and partial remissionTimepoint: 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimated GFR (eGFR) as measured by MDRD and adverse eventsTimepoint: at 6 and 12 months of treatment completion | — |
Countries
India
Contacts
Public ContactRaja Ramachandran
PGIMER
Outcome results
None listed