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Effects of intravenous clonidine or dexmedetomidine on change in heart rate and blood pressure during tracheal intubation

Effects of intravenous clonidine or dexmedetomidine on hemodynamic responses to laryngoscopy and endotracheal intubation and sedation: a randomized double blind clinical efficacy study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/10/004036
Enrollment
60
Registered
2013-10-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- American Society of Anaesthesiology physical status grade I and II, aged between 18-65 years of either sex, undergoing elective surgical procedures

Interventions

Intervention1: LARYNGOSCOPY AND TRACHEAL INTUBATION: LARYNGOSCOPY AND TRACHEAL INTUBATION Control Intervention1: Dexmedetomidine: A single intravenous dose of 1µg/kg over 10 min by an syringe pump b

Sponsors

SRI VENKATESWARA INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anaesthesiology physical status grade I and II 2.Aged between 18-65 years 3.Undergoing elective surgical procedures. 2.No history of allergies to study drugs.

Exclusion criteria

Exclusion criteria: 1. Patients not willing to participate in the study. 2. History of any cerebrovascular, neurological, cardiovascular, pulmonary, or metabolic disease. 3. Medications that would influence autonomic or cardiovascular response to intubation. 4. Risk of pulmonary aspiration (hiatus hernia, gastro-esophageal reflux). 5. History of neuromuscular disease that would make muscle relaxants contraindicated. 6. Predicted difficult intubation (Mallampati class III and IV).11 7. Heart rate 8. Pregnant and lactating patients. 9. Orthopedic and pediatric surgeries will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
To compare the hemodynamic parameters like heart rate, non-invasive blood pressure (NIBP) and mean arterial pressure (MAP), during laryngoscopy and tracheal intubation in both groups.Timepoint: 1.at base line 2.just before study drug infusion 3.after administration of study drugs(before induction of anesthesia4. 5.before laryngoscopy, and 6. First,second,third,fifth and tenth minutes after tracheal intubation.—

Secondary

MeasureTime frame
Sedation score to be assessed using Modified Observerâ??s Assessment of Alertness/Sedation ScaleTimepoint: 1. prior to study drug infusion 2.At the end of study drug infusion 3.After reversing neuromuscular blockade at the end of surgery—

Countries

India

Contacts

Public ContactAloka Samantaray

SRI VENKATESWARA INSTITUTE OF MEDICAL SCIENCES

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026