Health Condition 1: null- Biopsy proven rectal carcinoma stages II & III. ECOG performance status 0 to 3.
Conditions
Interventions
Control Intervention1: CONVENTIONAL VS HYPO-FRACTIONATED PRE-OPERATIVE RADIATION TREATMENT SCHEDULES: The investigator will observe those patients receiving pre-operative Radiotherapy of 25Gy in 5 fra
Sponsors
Government Medical College Thiruvananthapuram
Dr Bonny Natesh
Dr V S Santhosh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with biopsy proven rectal carcinoma stages II & III receiving either short-course or long-course of radiotherapy will be included in this study. 2.Patients with ECOG performance status 0 to 3. 3.Absolute granulocyte count more than 2000/mm3. 4.Platelet count greater than 100,000/mm3. 5.Renal function tests and Liver function tests are within normal limits.
Exclusion criteria
Exclusion criteria: 1.Patients with metastatic disease on diagnostic imaging during the course of study. 2.Patients with previous history of radiotherapy& treatment for GIT malignancy & history of chemotherapy. 3.Patients with history of treatment for any malignancy. 4.Associated serious medical illness like xerodermapigmentosa, renal failure, cardiac failure, hepatic failure. 5.Not giving consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| toxicity profile and extend of local control of the diseaseTimepoint: at the end of every two months following treatment completion | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactDr Sabarinath P S
Govt. medical college, Thiruvananthapuram
Outcome results
None listed