Health Condition 1: null- Acute Exacerbation of Asthma in children
Conditions
Interventions
Intervention1: Ketamine: Intravenous ketamine in dose of 0.5 mg/kg bolus over 20 minutes, followed by continuous infusion of 0.6 mg/kg/hour for 3 hours.
Control Intervention1: Aminophylline: Intraveno
Sponsors
Govt Medical college hospital Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1) Children 1 to 12 years of age with acute moderate to severe exacerbation of asthma; 2) Pediatric Respiratory Assessment Measure(PRAM) score >= 5 at 2 hours of standard therapy.
Exclusion criteria
Exclusion criteria: 1) Patients with history of prematurity, bronchopulmonary dysplasia, coexisting primary parenchymal pulmonary disease (e.g. cystic fibrosis) or coexisting congenital/acquired heart diseases. 2) Known hypertension 3) Known allergy to ketamine or aminophylline. 4) Raised intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in PRAM(Pediatric respiratory assessment measure) scoreTimepoint: at 15, 30, 60, 120 and 180 minutes after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects (vomiting, arrhythmias, hypotension, hypertension, dysphoric reactions, and oral secretions), change in pO2 and pCO2, change in PEFR, need for mechanical ventilation, and duration of hospital stay.Timepoint: at 15, 30, 60, 120 and 180 minutes after intervention except ABG which will be done at 0&180 mins | — |
Countries
India
Contacts
Public ContactVishal Guglani
Govt. medical college hospital, Chandigarh
Outcome results
None listed