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A study to assess Biological imaging before, during, and after Simultaneous Modulated Accelerated Radiation Therapy in head and neck squamous cell carcinoma .

Biological imaging before, during, and after Simultaneous Modulated Accelerated Radiation Therapy in head and neck squamous cell carcinoma . - (Bio-SMART)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2013/09/003988
Enrollment
20
Registered
2013-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Head Neck Squamous Cell Carcinoma

Interventions

Intervention1: Radiotherapy: This is observational and not an interventional study, patients will receive standard treatment as per their disease and stage.All patients entering into the study will b

Sponsors

Tata Memorial Centre Tata Memorial Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients >18 yrs and 2. Biopsy proven squamous carcinoma of the oropharynx, larynx or hypopharynx 3. T stage â?? T1 to T3 4. N stage â?? N1 to N2c 5. Planned for definitive non- surgical treatment (radiotherapy with or without systemic chemotherapy) 6. ECOG PS 0 to1

Exclusion criteria

Exclusion criteria: 1. Metastatic disease 2. Prior history of malignancy 3. Prior treatment interventions for the index malignancy (lymph node biopsies allowed)

Design outcomes

Primary

MeasureTime frame
To standardise the image acquisition with F-MISO PET.Timepoint: pre RT—

Secondary

MeasureTime frame
To assess changes in tumour characteristics using serial functional imaging with PET-CT (FDG & F-MISO) and MRI (DWI & DSC) in patients with HNSCC over a course of fractionated (chemo) radiotherapy.Timepoint: 9-12 months—

Countries

India

Contacts

Public ContactDr Tejpal Gupta

Tata Memorial Centre (Tata Memorial Hospital and ACTREC)

tgupta@actrec.gov.in912227405057

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026