Health Condition 1: null- patients with ECOG (0,1,2) - Good performance status
Conditions
Interventions
Intervention1: cisplatin , 5-Fu , radiotherapy ,surgery: Cisplatin will be administered in a dose of 20 mg/m2/day on day 1, 2, 3, 17, 18 and 19. 5-flurouracil will be administered in a dose of 750 mg/
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 2. Adenocarcinoma 3. Good performance status (Eastern Cooperative Oncology Group [ECOG] grades 0, 1 and 2) i.e the patient should not be spending more than 50% of his time in Bed. 4. Swallowing capacity at preop or preop neoadjuvant is a minimum of oral intake (liquid or semisolid) 5. Contrast enhanced computerized tomographic (CECT) scan suggesting a potentially resectable lesion. The features of resectability assessed on CECT scan will include - no evidence of infiltration of mediastinal structures such as the aorta (angle of contact 6. No evidence of distant metastasis on CECT of neck , thorax and abdomen.
Exclusion criteria
Exclusion criteria: 1. Patient refuses consent for the study 2. Co-morbid conditions which would preclude oesophagectomy a. Poor performance status (ECOG > 2) b. American Society of Anesthesiologists class IV 3. Metastatic disease detected on evaluation 4. Involvement of mediastinal structures as described in the inclusion criteria 5. Carcinoma involving upper third of the esophagus. 6. Previous radiotherapy or chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resectability rate, postoperative morbidity and operative mortalityTimepoint: resectability rate, postoperative morbidity and operative mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment compliance , early disease control (at 1 year) and assess the treatment toxicity of preoperative chemoradiation.Timepoint: till 2 years | — |
Countries
India
Contacts
Public ContactDrPeush Sahni
aiims
Outcome results
None listed