Health Condition 1: null- HIV infected adult individuals
Conditions
Interventions
Intervention1: Accelerated schedule ( 0,1,2 and 6 month): HBV vaccine administered at Accelerated schedule ( 0,1 and 6 month) with standard dose and double dose.
Control Intervention1: Standard schedu
Sponsors
Calcutta School of Tropical Medicine
Eligibility
Inclusion criteria
Inclusion criteria: 1) HIV seropositive patients above 20 years enrolled in the national ART Programme (Pre- ART & ART) as per NACO guideline. 2) Negative for any HBV serological marker. 3) Without any history of previous hepatitis B vaccination. 4) Willing to give written informed consent (by self).
Exclusion criteria
Exclusion criteria: 1. Currently positive for pregnancy test. 2. Associated life-threatening disease 3. Presence of any malignancy 4. Presence of associated co-infection with HCV, HAV or HEV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBV vaccination induced seroconversion rate will be higher for the accelerated schedule (0, 1, 2 and 6 month) than standard schedule (0, 1 and 6 month)and for the Double dose than standard dose.Timepoint: HBV vaccination induced seroconversion rate will be higher for the accelerated schedule (0, 1, 2 and 6 month) than standard schedule (0, 1 and 6 month)and for the Double dose than standard dose. | — |
Secondary
| Measure | Time frame |
|---|---|
| HBV seroconversion rate may be associated with high HIV viral load and low CD4 countTimepoint: CD4 count and HIV viral load measured before first dose of HBV vaccine. | — |
Countries
India
Contacts
Public ContactSubhasish Kamal Guha
Calcutta School of Tropical Medicine
Outcome results
None listed