Effect of dexmedetomidine and magnesium sulphate on propofol consumption, haemodynamics (blood pressure and heart rate) and postoperative recovery in spine surgery

Comparative evaluation of dexmedetomidine and magnesium sulphate on propofol consumption, haemodynamics and postoperative recovery in spine surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/08/003939

Enrollment

Registered

2013-08-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I or II patient, Non diabetic, Non hypertensive and require General anesthesia with intubation

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine loading dose 1mcg/kg before induction over a period of 15 min and maintenance 0.5 mcg/kg/h throughout the surgery via intravenous (IV) route Intervent

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I and II, 2.Non hypertensive and non diabetic 3.Scheduled for spinal surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Known allergy to magnesium sulphate or other study drug, 2.Morbid obesity (body mass index >40), 3.Chronic use of opioids and anticoagulants 4.Current treatment with a ß-blocker or calcium channel blocker 5.Diabetes and hypertension 6.Known asthma or reactive airway disease, 7.Hepatic, renal or cardiovascular dysfunction 8.Any degree of heart block 9.Haematological disorder 10.History of neuromuscular disease, 11.Patients receiving magnesium supplementation, 12.Drugs known to have a significant interaction with NMDAs 13.Psychiatric patients 14.Pregnant and lactating women

Design outcomes

Primary

Measure	Time frame
To study the effect of dexmedetomidine and magnesium sulphate on propofol consumption and haemodynamics in spine surgery.Timepoint: (A) Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and bispectral index (BIS) will be continuously monitored and recoreded at following time intervals 1)Preop 2)After study drug 3)After induction 4)After intubation 5)Intraop period at 20 min intervals 6)After surgery 7) After extubation (B) Propofol requirement hourly	—

Measure

Time frame

To study the effect of dexmedetomidine and magnesium sulphate on propofol consumption and haemodynamics in spine surgery.Timepoint: (A) Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and bispectral index (BIS) will be continuously monitored and recoreded at following time intervals 1)Preop 2)After study drug 3)After induction 4)After intubation 5)Intraop period at 20 min intervals 6)After surgery 7) After extubation (B) Propofol requirement hourly

—

Secondary

Measure	Time frame
(1)Postoperative recovery parameters - Extubation time – - Response to verbal commands -Time for orientation (2)To study the adverse effects of dexmedetomidine.Timepoint: Fentanyl and muscle relaxant requirement hourly	—

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

abhimishraa@gmail.com9669980275

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026