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Use of nifedipine as maintenance therapy to decrease preterm labor

MAINTENANCE TOCOLYSIS IN PRETERM LABOUR WITH NIFEDIPINE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/08/003916
Enrollment
50
Registered
2013-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: tablet Nifedipine: Nifedipine is drug of choice for tocolysis in cases of preterm labour. In present trial Nifedipine was used as a MAINTENANCE TOCOLYSIS in study group after cessation

Sponsors

ajay aggarwal
Lead Sponsor
PGIMER chandigarh
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Singleton pregnancy from 26 to 33+6/7 weeks of gestation with intact membranes with arrested preterm labour PRETERM LABOUR: women with regular uterine contractions at a frequency of 4 per 20 minutes or 8 per 60 minutes, and accompanied by one of the following- cervical dilation >2cm or effacement >50% If cervical findings were uncertain then transvaginal ultrasound measured cervical length ARRESTED PRETERM LABOUR: women who presented with preterm labour, received acute tocolysis and achieved uterine quiescence (defined as less than four contractions per hour for 12 hours or without progression of labour after 48 hours of acute tocolysis)

Exclusion criteria

Exclusion criteria: 1. Antepartum haemorrhage (Abruption placentae and Placenta praevia) 2. Fetal or maternal indication for termination of pregnancy 3. Fetal death or major congenital anomalies incompatible with life 4. Multiple gestation 5. Cervical dilatation >4cm 6. Contraindication to nifedipine (hypersensitivity, left ventricular dysfunction, congestive heart failure, renal disease, hypotension i.e. BP 7. Hypertension (chronic HT, gestational HT, pre-eclampsia)

Design outcomes

Primary

MeasureTime frame
Achievement of 37 weeks of gestation.Timepoint: JULY 2011 to DECEMBER 2012—

Secondary

MeasureTime frame
1. Latency in term of number of days gained after the episode of preterm labour till delivery occurs. 2. Neonatal mortality and morbidity in terms of respiratory distress syndrome, intra-ventricular haemorrhage, necrotising enterocolitis and neonatal ICU (NICU) admission and stay in NICU.Timepoint: JULY 2011 to DECEMBER 2012—

Countries

India

Contacts

Public Contactajay aggarwal

PGIMER

rashmibagga@gmail.com919914209349

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026