Health Condition 1: null- Plaque psoriasis
Conditions
Interventions
Intervention1: Pioglatazone: Group B: Active treatment: Pioglitazone 15 mg tablets once daily orally for 12 weeks.
Intervention2: Methotrexate + Pioglitazone combination.: Group C : Combination therap
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: •Age >= 18 years and less than 65 years. •New cases of Plaque psoriasis vulgaris >= 10% (apart from palmoplantar psoriasis which will be included). •Older cases of Plaque psoriasis vulgaris showing relapse after 4 wks of stopping the systemic treatment or patients who have left the treatment for 4 wks or more
Exclusion criteria
Exclusion criteria: •Age less than 18 years and more than 65 years •Mild psoriasis less than 10% body surface area •Erythrodermic, pustular psoriasis or guttate psoriasis. •Liver disease, cardiac disease (History of CHF), renal failure or any other major medical disorder detected by history. •Pregnant and lactating females. •Known contraindication to pioglitazone or methotrexate •Patient with active bladder cancer or with a prior history of bladder cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy â?¢Treatment success detected as clinical improvement of skin condition â?¢% PASI improvement from baseline Timepoint: At 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢Treatment success detected as clinical improvement of skin condition â?¢% PASI improvement from baseline Timepoint: At 12 weeks | — |
Countries
India
Contacts
Public ContactDr AFROZ ABIDI
Subharti Medical College, Meerut
Outcome results
None listed