To see the effect of different gases for airway cuff inflation

Comparison of effect of Air, O2, Air: O2 mixture and O2:N2O mixture used for LMA cuff inflation on cuff pressure, ventilatory parameters and pharyngolaryngeal morbidity in adults - a prospective, randomised, double blind, comparative study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/08/003888

Enrollment

120

Registered

2013-08-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- for surgery under general anesthesia with LMA with no end organ failure

Interventions

Intervention1: 100% oxygen, oxygen air mixture 50:50, oxygen nitrous oxide mixture 50:50: the mixtures of different gases were aspirated in the syringes from common gas outlet of the anesthesia machin

Eligibility

Inclusion criteria

Inclusion criteria: a) Above 18 years b) General anaesthesia with proseal LMA (PLMA) c) Duration of anaesthesia >= 30 minutes

Exclusion criteria

Exclusion criteria: a) Recent history of upper respiratory tract infection b) Contraindication to the use of LMA such as symptomatic hiatus hernia, or severe gastroesophageal reflux disease. C) Preoperative nerve palsy.

Design outcomes

Primary

Measure	Time frame
To evaluate the changes in LMA cuff pressure with general anaesthesia using O2 : N2O anaesthesia with different gases used to inflate the LMA cuffTimepoint: from the start of nitrous oxide till the nitrous oxide will be switched off i.e. from the start of surgery till the end of surgery	—

Secondary

Measure	Time frame
1 To evaluate the changes in patientâ??s ventilatory parameters as tidal volume (insp/exp), respiratory rate, inspiratory peak airway pressure and EtCO2 with change in LMA cuff pressure. 2 To evaluate the incidence of pharyngolaryngeal morbidities i.e. sore throat, dysphagia, dysphonia, nerve palsies with changes in LMA cuff pressure. Timepoint: 1. from the start of surgery till the end of surgery 2. from the end of surgery till 24 hours postoperative period	—

Measure

Time frame

1 To evaluate the changes in patientâ??s ventilatory parameters as tidal volume (insp/exp), respiratory rate, inspiratory peak airway pressure and EtCO2 with change in LMA cuff pressure. 2 To evaluate the incidence of pharyngolaryngeal morbidities i.e. sore throat, dysphagia, dysphonia, nerve palsies with changes in LMA cuff pressure. Timepoint: 1. from the start of surgery till the end of surgery 2. from the end of surgery till 24 hours postoperative period

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Countries

India

Contacts

Public ContactRenu Sinha

All India Institute of Medical Sciences, New Delhi

renuagarwal4@rediffmail.com9868397822

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026