A clinical trial to study the effects of dexmedetomidine drug on laryngoscopy and tracheal intubation during the administration of general anesthesia.

A clinical study to evaluate the role of preoperative dexmedetomidine on attenuation of haemodynamic response to direct laryngoscopy and tracheal intubation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/08/003885

Enrollment

Registered

2013-08-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dexmedetomidine: A clinical study to evaluate the role of preoperative dexmedetomidine on attenuation of haemodynamic response to direct laryngoscopy and tracheal intubation. Interventi

Eligibility

Inclusion criteria

Inclusion criteria: 1.80 adult patients of ASA (American Society of Anesthesiologists) physical status I /II of either sex 2.Age group of 18 to 60 years 3.Scheduled to undergo elective surgery under general anaesthesia requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: The following categories of patients were excluded from the study: 1. ASA grade III or more 2. Anticipated difficult airway 3. BMI >30 kg m 2 4. Preoperative medication with clonidine or alphamethyldopa 5. Hiatus hernia, gastroesophageal reflux 6. Known allergy to dexmedetomidine 7. Known case of coronary artery disease

Design outcomes

Primary

Measure	Time frame
To study the effect of dexmedetomidine given before induction of anaesthesia on haemodynamic responses to direct laryngoscopy and tracheal intubation.Timepoint: Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP), Oxygen Saturation (SpO2), end tidal CO2 (EtCO2) were continuously monitored and recorded at following time intervals. - Baseline - After completion of infusion of study drug - 5 min after completion of infusion of study drug - After induction - Just before intubation - After intubation at 1min, 3min, 5min, 10min and 15 min.	—

Measure

Time frame

To study the effect of dexmedetomidine given before induction of anaesthesia on haemodynamic responses to direct laryngoscopy and tracheal intubation.Timepoint: Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP), Oxygen Saturation (SpO2), end tidal CO2 (EtCO2) were continuously monitored and recorded at following time intervals. - Baseline - After completion of infusion of study drug - 5 min after completion of infusion of study drug - After induction - Just before intubation - After intubation at 1min, 3min, 5min, 10min and 15 min.

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Secondary

Measure	Time frame
1)To study effect of dexmedetomidine on requirement of propofol at induction. 2)To study the adverse effects of dexmedetomidine. Timepoint: - After recording the primary outcome observations for 15 the rest of the anaesthetic procedure was carried out. The secondary outcomes were recorded during the study which includes the the total dose of propofol required for induction and any adverse effects of dexmedetomidine during the entire study was recorded.	—

Measure

Time frame

1)To study effect of dexmedetomidine on requirement of propofol at induction. 2)To study the adverse effects of dexmedetomidine. Timepoint: - After recording the primary outcome observations for 15 the rest of the anaesthetic procedure was carried out. The secondary outcomes were recorded during the study which includes the the total dose of propofol required for induction and any adverse effects of dexmedetomidine during the entire study was recorded.

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Countries

India

Contacts

Public ContactDR KAMLESH KUMARI

Govt. Medical College and Hospital, Chandigarh

kapoor.dheeraj72@gmail.com91-9646121549

Outcome results