Health Condition 1: null- Severe malaria(P vivax and P falciparum) Non malarial fever Healthy participants
Conditions
Interventions
Intervention1: Host immune response: Expression levels of the identified serum protein sample (200 microlitre)in severe malaria patients will help to correlate the identified marker proteins with dise
Sponsors
Department of Biosciences and Bioengineering Indian Institute of Technology
Eligibility
Inclusion criteria
Inclusion criteria: Participants of either sex aged 18 to 65 years both inclusive Either gender with a diagnosis of severe/complicated vivax malaria OR with a diagnosis of severe malaria due to mixed infection Confirmed nonmalaria fever patients dengue fever (serum IgM antibody titre) leptospirosis (microscopic agglutination test)and enteric fever (widal test) Healthy volunteers as judged by medical history clinical examination and laboratory investigations Patients or their legally accepted representatives willing to provide written informed consent
Exclusion criteria
Exclusion criteria: Patients with history of significant systematic disease like autoimmune disorders chronic liver diseases psychiatric illness and bleeding disorders etc As judged by history and physical examination Patients with a diagnosis of complications to dengue leptospirosis or any other infectious disease A female patient who is pregnant at enrolling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum proteome analysis of patients suffering from severe P vivax and P falciparum malaria infections to get mechnistic insights about disease pathogenesis and host immune response Identification of potential serum markers associated with severe versus uncomplicated malaria Correlation of the identified serum markers with disease severity establishment of prognostic host markers of malaria Timepoint: single time | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Nithya Gogtay
Department of Bio sciences and Bioengineering IIT
Outcome results
None listed