Health Condition 1: null- Hypertension in pregnancy Health Condition 2: O268- Other specified pregnancy relatedconditions
Conditions
Interventions
Intervention1: Oral methyldopa: Oral myethyldopa 1000mg every 6h for up to 6 hours
Intervention2: Labetalol: Oral labetalol 200mg. If BP exceeds 155mmHg systolic or 105mmHG diastolic after 1h, an addi
Sponsors
Gynuity Health Projects
Eligibility
Inclusion criteria
Inclusion criteria: • Pregnant gestational age > 28 weeks • Systolic blood pressure >160 mm Hg OR a diastolic blood pressure of >110 mm Hg measured twice more than 15 minutes apart • Able to swallow pills • > 18 years
Exclusion criteria
Exclusion criteria: • Indication for emergent cesarean or known fetal anomaly • Anti-hypertensive therapy received in the past 6 hours • History of eclampsia or other adverse CNS complication (e.g., stroke or PRES) in this pregnancy • Actively wheezing at time of enrollment or history of asthma complications • Known coronary artery disease or type I DM with microvascular complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful outcome will be considered blood pressure that reaches the target (defined as 130-150mmHg systolic and 80-100 mmHg mm Hg diastolic) at 6h without an adverse outcome. Adverse outcomes include hypotension (systolic blood pressure, 120 mm Hg and/or diastolic blood pressure 70 mm Hg and fetal compromise), caesarean section for fetal distress, severe headache and severe headache requiring discontinuation of drug, or eclampsia.Timepoint: Six hours after drug administration | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ the number of hourly BPâ??s in severe rangeTimepoint: every hour after drug administration | — |
Countries
India
Contacts
Public ContactShuchita Mundle
Outcome results
None listed