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effect of dexmedetomidine during general surgery

Clinical evaluation of dexmedetomidine on haemodynamic stress response during laryngoscopy and intubation-a randomized, double blind, parallel group, placebo controlled study.

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/07/003820
Enrollment
100
Registered
2013-07-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- endotracheal intubation

Interventions

Intervention1: Inj.Dexmedetomidine: As pre-medication,1mcg/kg in 100 ml normal saline intravenous infusion over 15-20 minutes,30 minutes before induction.Blood pressure,heart rate,oxygen saturation ar

Sponsors

Dept of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -Patients posted for elective surgery under general anaesthesia requiring endotracheal intubation. -ASA physical status I and II. -BMI -Informed written consent for participation in study.

Exclusion criteria

Exclusion criteria: -Patients with diabetes, renal disease, cardiac diseases like IHD, Hypertension. -Patients on drugs, having effects on heart rate and blood pressure (sedatives, opioids, β blockers, calcium channel blockers) and anti-psychiatric drugs. -Pregnant women and lactating mothers. -Anticipated difficult intubation. -Intubation attempt lasting longer than 20 seconds.

Design outcomes

Primary

MeasureTime frame
Blunting in haemodynamic stress response during laryngoscopy and intubation.Timepoint: Blood pressure,heart rate,oxygen saturation are recorded starting from baseline to infusion and then upto 30 minutes after intubation.

Secondary

MeasureTime frame
Sedative effect after infusion.Timepoint: Sedation score will be recorded baseline and then after infusion of drug till induction.

Countries

India

Contacts

Public ContactNaveen Kumar Gour

Govt.Medical College,Bhavnagar

shah.komal@rediffmail.com9427215252

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026