COMPARISION OF EFFECTIVENESS OF DEXMEDETOMIDINE(A MULTIPURPOSE DRUG USED IN ANAESTHESIA) VS ESMOLOL(USED FOR CONTROL OF HIGH BP & HEART RATE) IN DECREASING THE HYPERTENSION & TACHYCARDIA OCCURING DURING PASSAGE OF BREATHING TUBE INTO LUNGS IN PATIENTS WITH HIGH BP WHO ARE ON TREATMENT

COMPARISION OF EFFECTIVENESS OF DEXMEDETOMIDINE VS ESMOLOL IN BLUNTING OF CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN TREATED HYPERTENSIVES

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/06/003741

Enrollment

Registered

2013-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Hypertensive patients on treatment with good control of blood pressure

Interventions

Intervention1: DEXMEDETOMIDINE: INJ. DEXMEDETOMIDINE 1Âµg/kg IV infusion over 10 minutes, to be completed ten minutes before anaesthesia is induced Intervention2: Esmolol: Inj.ESMOLOL 1mg/kg IV bolus,

Eligibility

Inclusion criteria

Inclusion criteria: Ninety patients of ASA physical status II & III, of either sex, aged between 35-65 years and undergoing elective surgery requiring general anaesthesia will be included in the study. Controlled hypertensive patients with blood pressure less than 160/100 mmHg receiving oral antihypertensive medication for a minimum period of six weeks will be studied.

Exclusion criteria

Exclusion criteria: ? Patients with anticipated difficult intubation ? Physical status > ASAIII ? Hiatus hernia, gastro-oesophageal reflux disease ? Obesity ( BMI > 30 kg/m2) ? Those on long-term sedatives, hypnotics, antidepressants, drugs affecting nervous system ? Previous myocardial infarction or angina pectoris, congestive heart failure ? Heart blocks ? Neurosurgical patients ? History of allergy to dexmedetomidine or esmolol

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of dexmedetomidine versus esmolol in blunting of the hemodynamic and bispectral index(BIS) response to laryngoscopy and intubation in treated hypertensive patients undergoing elective surgeryTimepoint: It will be a randomized double- blind study conducted between january 1st 2011 to December 31st 2011(one year).	—

Secondary

Measure	Time frame
The study also aims at measuring dexmedetomidineâ??s effect on isoflurane requirements.Timepoint: It will be a randomized double- blind study conducted between january 1st 2011 to December 31st 2011(one year).	—

Countries

India

Contacts

Public ContactKIRAN BHARATH

PGIMER

podder_s@yahoo.co.in9914209526

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026