Health Condition 1: K746- Other and unspecified cirrhosis ofliver Health Condition 2: null- variceal bleed
Conditions
Interventions
Intervention1: Octreotide Infusion following endoscopic therapy in variceal bleed: 2 days 50microgram/hr infusuion
Control Intervention1: Octreotide Infusion following endoscopic therapy in variceal b
Sponsors
Jawaharlal Institute of Post graduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: - Patient presenting with upper gastrointestinal bleeding with portal hypertension diagnosed by clinical, biochemical, radiological investigation and presence of esophageal varices confirmed on endoscopy. - First episode of variceal bleed. - Age 13 years and above. - Patient undergoing endoscopic therapy.
Exclusion criteria
Exclusion criteria: - Concomitant gastric varices or any other additional upper gastrointestinal source of bleed - Hepatocellular carcinoma / any other malignancy - Debilitating illness like cerebro vascular accident, severe ischemic heart disease - Use of vasoactive medicines & endoscopic therapy before being referred to our hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To assess and compare the efficacy of 2 days versus 5 days of infusion of octreotide in preventing early rebleed along with endosocpic therapy.Timepoint: 2 days and 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| - To assess the factors associated with the outcome in different treatment arms. - To assess the costeffectiveness of 2 days versus 5 days of infusion in preventing early rebleed along with endosocpic therapy. Timepoint: 2 and 5 days | — |
Countries
India
Contacts
Public ContactSudhagar R
JIPMER
Outcome results
None listed