Health Condition 1: null- Hepatocellular Carcinoma.
Conditions
Interventions
Intervention1: Three dimensional conformal radiotherapy.: Three dimensional conformal radiotherapy to the liver lesion for which the dose will be based on NTCP model for liver and Dose Volume histogr
Sponsors
Regional Cancer Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patients who are not suitable for standard curative treatments of hepatocellular carcinoma. 2) Histological/cytological diagnosis of hepatocellular carcinoma or a patient with radiologically hyper-vascular liver tumour and a serum alpha-fetoprotein level >400ng/ml without evidence of any other alpha-fetoprotein secreting tumor. 3) Single tumour of size less than or equal to 10cms or two tumours of size less than or equal to 5cms. 4) Child Pugh Class A & B. 5) No evidence of distant metastasis. 6)Informed consent
Exclusion criteria
Exclusion criteria: 1) Pregnancy. 2) Patient who had prior radiotherapy to the treatment area. 3) Other concomitant severe systemic diseases 4)ECOG performance status of 2 or worser.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Assessment of objective response of hepatocellular carcinoma to high dose conformal external beam radiotherapy. 2)Evaluation of hepatic toxicity to radiotherapy at 6 weeks after radiation Timepoint: 6 weeks after completion of radiotherapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Median SurvivalTimepoint: 3 months after radiotherapy | — |
Countries
India
Contacts
Public ContactDr C D Sivanandan
Regional Cancer Centre,Trivandrum.
Outcome results
None listed