A clinical trial comparing two drugs palonosetron and dexamethasone and their combination for prevention of post operative nausea and vomiting of patient undergoing laparoscopic cholecystectomy operation

Antiemetic prophylaxis against postoperative nausea and vomiting with palonosetron-dexamethasone combination compared with palonosetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/05/003630

Enrollment

Registered

2013-05-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patient undergoing laparoscopic cholecystectomy operation

Interventions

Intervention1: Palonosetron: 0.075 mg palonosetron single dose intravenously preoperatively just before induction of anaesthesia. Control Intervention1: dexamethasone: 8 mg dexamethasone single dose i

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE I-II

Exclusion criteria

Exclusion criteria: 1. History of motion sickness 2. Pregnancy or menstruation 3. Co-existing GI pathology 4. Smokers 5. Chronic antiemetic medication

Design outcomes

Primary

Measure	Time frame
Absence or decreased incidence of post operative nausea- vomiting in patients of laparoscopic cholecystectomyTimepoint: 6, 12, 24 hr	—

Secondary

Measure	Time frame
HR, MAP, Ramsay Sedation ScoreTimepoint: 6, 12, 24 hr	—

Countries

India

Contacts

Public ContactDrArindam Chatterjee

Sanjay Gandhi Post Graduate Institute of Medical Sciences

arindamchatbkp@gmail.com8004967783

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026