This is a clinical study to find the ideal combination of anesthesia inducing agents (such as propofol, etomidate or thiopentone) with dexmedetomidine as a premedicant, for attenuation of adverse hemodynamic effects produced due to laryngoscopy and tracheal intubation.

Comparison of hemodynamic response to laryngoscopy and tracheal intubation following combination of dexmedetomidine as premedicant with three different induction agents: propofol, etomidate and thiopentone

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/05/003606

Enrollment

Registered

2013-05-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients posted for different neurosurgical procedures

Interventions

Intervention1: dexmedetomidine with propofol: Dexmedetomidine as premedicant: 1 microgram/kg of body weight over 10 minutes as bolus dose before the injection of induction agent followed by 0.5 microg

and propofol 2 mg/kg of body weight for induction Control Intervention1: dexmedetomidine with etomidate: Dexmedetomidine as premedicant: 1 microgram/kg of body weight over 10 minutes as bolus dose b

and etomidate 0.3 mg/kg of body weight for induction of anesthesia Control Intervention2: dexmedetomidine with thiopentone: Dexmedetomidine as premedicant: 1 microgram/kg of body weight over 10 minu

and thiopentone 5 mg/kg of body weight for induction

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II patients, patients posted for various type of elective neurosurgery procedures

Exclusion criteria

Exclusion criteria: Patients with cardiac diseases, hypertension disorder, diabetes, hepatic or renal function disorder; Patients who have shown hypersensitivity to any of the drugs used in this study; Patients with CL grade 3 and 4; Patients who need intubation assistance other than using a Stylet; Patients who could not be intubated on single attempt; Patients with previous history of difficult intubation

Design outcomes

Primary

Measure	Time frame
Mean blood pressure, heart rateTimepoint: Baseline before any medication At 0 minute just before laryngoscopy Then every 1 minute interval at 1 minute, 2 minute, 3 minute, 4 minute, 5 minute	—

Secondary

Measure	Time frame
Mean blood pressure and heart rateTimepoint: 10 minutes after the initiation of laryngoscopy	—

Countries

India

Contacts

Public ContactDR SASWATA BHARATI

esbee77@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026