To assess if the use of EEG monitoring during anaesthesia i.e. Entropy monitoring can help in assessing propofol requirement in patients undergoing laryngeal surgery under total intravenous anaesthesia with or without the use of an additive drug dexmedetomidine

Entropy monitoring for titrating target controlled infusion(TCI)requirements of propofol in adults undergoing laryngeal surgery under total intravenous anaesthesia(TIVA)with or without supplementary dexmedetomidine infusion

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/05/003605

Enrollment

Registered

2013-05-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J38- Diseases of vocal cords and larynx, not elsewhere classified Health Condition 2: null- Patients aged 18-65 years undergoing surgery performed on the larnyx using suspension laryngoscopy

Interventions

Intervention1: entropy monitoring for titrating target controlled infusion levels of propofol in patients undergoing laryngeal surgery under total intravenous anaesthesia: entropy monitor is a modifie

Eligibility

Inclusion criteria

Inclusion criteria: This study will be conducted in the Department of Anaesthesiology at All India Institute of Medical Sciences after obtaining Institutional Ethics committee approval. 60 ASA I and II patients, 18-65 years, undergoing laryngotracheal procedures requiring suspension laryngoscopy, rigid bronchoscopy will be included in this study after taking informed consent

Exclusion criteria

Exclusion criteria: 1.Patients who have neurological deficit following head injury, epilepsy etc. which can interfere with entropy monitoring. 2. Patients who are morbidly obese (BMI >35kg/m2). 3. Patients on Î² blockers, clonidine, verapamil.

Design outcomes

Primary

Measure	Time frame
The primary aim of the study is to evaluate the effect-site concentration (Ce) of propofol needed for laryngeal surgeries by using the entropy monitor to titrate the depth of anesthesiaTimepoint: the study involves titrating intraoperative requirement of propofol	—

Secondary

Measure	Time frame
To assess- 1. if the target controlled infusion (TCI) propofol requirement during total intravenous anaesthesia(TIVA) is decreased with the concomittant use of dexamedetomidine infusion 2. whether concomittant use of dexmedetomidine with the TCI-TIVA propofol results in faster awakening of patients after laryngeal surgery 3. if the concomittant use of dexmedetomidine with the TCI-TIVA propofol results in lesser intraoperative haemodynamic variations in patients undergoing laryngeal surgery.Timepoint: Intraoperative requirement of the drugs will be titrated	—

Measure

Time frame

To assess- 1. if the target controlled infusion (TCI) propofol requirement during total intravenous anaesthesia(TIVA) is decreased with the concomittant use of dexamedetomidine infusion 2. whether concomittant use of dexmedetomidine with the TCI-TIVA propofol results in faster awakening of patients after laryngeal surgery 3. if the concomittant use of dexmedetomidine with the TCI-TIVA propofol results in lesser intraoperative haemodynamic variations in patients undergoing laryngeal surgery.Timepoint: Intraoperative requirement of the drugs will be titrated

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Countries

India

Contacts

Public ContactAnjolie Chhabra

All India Institute of Medical Sciences

anjolie5@hotmail.com09868397814

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026