Health Condition 1: null- Alcohol Withdrawal Syndrome
Conditions
Interventions
Intervention1: Baclofen 10 mg: Baclofen 10 mg in following schedule TID up to 3 days, BD up to 3 days and OD up to 3 days
Control Intervention1: Chlordiazepoxide 25mg: Chlordiazepoxide 25mg in followi
Sponsors
Dr VIKRAM REDDY K
Eligibility
Inclusion criteria
Inclusion criteria: a. Subjects with alcohol dependence according to DSM-IV (TR) criteria. b. Last alcohol intake within 24 hour preceding the initiation of study. c. Willingness to give written informed consent.
Exclusion criteria
Exclusion criteria: a. Patients with known psychiatric disorders. b. Patients with known renal and cardiovascular diseases. c. Patients with known allergy to study medications. d. Patients with multi-drug abuse. e. Patients with any other substance dependence except nicotine. f. Patients with delirium tremens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of baclofen with chlordiazepoxide in AWS as assessed by Clinical Institute Withdrawal Assessment of Alcohol Scale Revised (CIWA-Ar score). Primary Outcome: lowering in CIWA-Ar severity scores.Timepoint: 10 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression(CGI) Scales. 1.Decrease in CGI-severity scale. 2.Increase in CGI-improvement scale and 3.Change in CGI-efficacy index score according to therapeutic and side effects.Timepoint: 10 days | — |
Countries
India
Contacts
Public ContactDr GIRISH K
KEMPEGOWDA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed