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Comparatative study on the effectivness of Granisetron(antiemetic) and Metoclopramide(antiemetic) for reducing Propofol(intravenous inducing agent) injection pain.

Comparatative study on the effectivness of Granisetron and Metoclopramide for reducing Propofol injection pain.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2013/04/003570
Enrollment
800
Registered
2013-04-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pain During Propofol injection for elective general anaesthesia.

Interventions

Intervention1: Granisetron: All patients will be fasted for 8hrs and will receive 150mg rannitidine in evening and on day of surgery.Patients will be randomized using a computer generated random numb
15s later,the patient was asked to rate immediately any sensation of pain during propofol injection.Thereafter induction of anaesthesia will be achieved with propofol and for analgesia ,fentanyl 2u
15s later,the patient was asked to rate immediately any

Sponsors

Government Medical college thiruvananthapuram
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient Refusal. 2.Adults in age group 21-50 years.

Exclusion criteria

Exclusion criteria: 1.Patient refusal. 2.ASA(PS) 3&above. 3.Age 50 yrs. 4.Neurological deficit. 5.History of allergy to propofol,metoclopramide and granisetron. 6. History of taking any analgesics before surgery. 7.History of diabetes or hypertension. 8.History of Cardiovascular or respiratory disease. 9.Morbid obesity. 10.Emergency surgery.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of granisetron and metoclopramide for propofol injection pain.Timepoint: 12 months

Secondary

MeasureTime frame
To compare the effectiveness of granisetron and metoclopramide for post operative nausea and vomiting.Timepoint: 12 months

Countries

India

Contacts

Public ContactAravind Johnson

Government Medical College Thiruvananthapuram

harikrishnans248@gmail.com9847160680

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026