Health Condition 1: null- Hypertensive American Society of Anesthesiologists (ASA) 2 physical status
Conditions
Interventions
Intervention1: Dexmedetomidine (selective alpha-2 agonist): Loaded as a 2mcg/ml solution in 50ml NS. Loading dose 1mcg/kg infusion given over 10 minutes intravenously. Changed over to maintenance dose
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Hypertensive patients under American Society of Anesthesiologists (ASA) Physical status 2 posted for major surgery under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Systolic BP > 160mmHg, Diastolic BP >100mmHg 2. H/o ischemic heart disease 3. H/o cerebral vascular disease 4. Impaired renal function tests 4. Impaired liver function tests 5. Laparoscopic procedure 6. Pregnant and suspected full-stomach patients 7. Anticipated difficult airway 8. Surgery with expected significant blood loss ( >25%of blood volume) and fluid shifts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effect of intravenous Dexmedetomidine on intra operative hemodynamics in hypertensive patients and compare it with The effect of intravenous FentanylTimepoint: To study the effect of intravenous Dexmedetomidine on intra operative hemodynamics in hypertensive patients and compare it with The effect of intravenous Fentanyl | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption Timepoint: Intra operative ;Time to recover from anesthesia (eye opening to verbal call)Timepoint: End operative;Time to first analgesic requestTimepoint: Post operative | — |
Countries
India
Contacts
Public ContactKanchan V Bilgi
JIPMER
Outcome results
None listed