Health Condition 1: null- patients posted for spine surgery without any major systemic co morbidities.
Conditions
Interventions
Intervention1: dexmedetomidine: To compare the effect of dexmedetomidine to a placebo on requirements of propofol as maintenance anaesthetic agent in elective spinal surgery under general anaesthesia.
Sponsors
Institute of Post Graduate Medical Education And Research
Eligibility
Inclusion criteria
Inclusion criteria: Age : 20 â?? 60 yrs Sex : male and female ASA-PS status : I or II Duration of surgery: Within 2 to 3 hrs.
Exclusion criteria
Exclusion criteria: Patient refusal. Uncontrolled hypertension, higher degree A-V block. H/O COPD, obstructive sleep apnea. Documented hepatic , G-I tract, renal, haematological, psychiatric illness, and seizure disorder. H/ O allergy. patient with alcohol abuse. Pregnancy and breast feeding. Morbid obesity. Patients on chronic opioid analgesic , TCA , clonidine, MAO-Inhibitor therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe the effect of continuous dexmedetomidine infusion on total dose of propofol requirement for maintenance of optimum level anaesthesia in elective spinal surgery.Timepoint: Throughout the duration of the procedure i.e. from the time of induction of anaesthesia till extubation of the patient | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the total requirement of fentanyl during intra operative period between the two groups. To compare haemodynamic status between above two groups after induction, during laryngoscopy and intubation, at the time of skin incision, and throughout the intra operative period. To compare the recovery profile between two groups as assessed by Ramsay sedation scale. to observe any other adverse consequences among the patientsTimepoint: 15 min before starting induction of anaesthesia to 15 min after extubation of the patients | — |
Countries
India
Contacts
Public ContactSUVADEEP SEN
Bangur Institute of Neurosciences and Institute of Post Graduate Medical Education and Research
Outcome results
None listed