Role of intraoperative and postoperative fluid restriction on postoperative outcomes after esophagectomy â?? a prospective randomized controlled trial

Role of intraoperative and postoperative fluid restriction on postoperative outcomes after esophagectomy â?? a prospective randomized controlled trial - FRES

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/03/003496

Enrollment

324

Registered

2013-03-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- intraoperative and postoperative fluid restriction on postoperative outcomes after esophagectomy

Interventions

Intervention1: Restricted fluid administration: Perioperative fluid administration targeted at an hourly urine output of 0.5 ml/kg/hour Control Intervention1: Conventional (liberal) fluid administrati

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with biopsy or cytology proven (squamous or adenocarcinoma) esophageal cancer 2. Patients with staging investigations indicating operability 3. Surgical plan for total transthoracic or transhiatal esophagectomy 4. American Society of Anesthesiologists (ASA) grade I, II

Exclusion criteria

Exclusion criteria: 1. Patients with low performance status (ECOG score > 1) 2. Patients with pre existing renal or liver disease 3. Patients with ischemic heart disease 4. Patients below 18 years and above 70 years of age.

Design outcomes

Primary

Measure	Time frame
Pulmonary complications in the two groupsTimepoint: Pulmonary complications in the two groups	—

Secondary

Measure	Time frame
1. Need for postoperative ventilation 2. Duration of postoperative ventilation 3. Need for tracheostomy for pulmonary toilet 4. Need for frequent bronchoscopies (5) Timepoint: 1. Need for postoperative ventilation 2. Duration of postoperative ventilation 3. Need for tracheostomy for pulmonary toilet 4. Need for frequent bronchoscopies (5)	—

Countries

India

Contacts

Public ContactDrCS Pramesh

Tata memorial Cancer Hospital

cspramesh@gmail.com022-24177070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026