Health Condition 1: null- Hypertensive patients with vitamin D deficiency
Conditions
Interventions
Intervention1: Oral Vitamin D3: Oral Vitamin D3 60000 IU per week for 8 weeks
Intervention2: Vitamin D3: 60000 IU once a week orally, for 8 weeks
Control Intervention1: No comparator: No comparator
Sponsors
Jawaharlal Institute of Post Graduate Medical Education and Research JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Hypertensive patients on treatment with vitamin D deficiency (serum 25 OH vitamin D3 less than 20 ng/ml)
Exclusion criteria
Exclusion criteria: Subjects taking any vitamin, minerals or herbal medications Subjects on any medications known to affect calcium or vitamin D metabolism such as corticosteroids, anti-epileptics Hepatic impairment Renal dysfunction Dermatological disorder Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameters of arterial stiffness- pulse wave velocity (PWV) (cm/s), arterial stiffness index (ASI) (mmHg) Timepoint: at baseline and after 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood levels of malondialdehyde and total antioxidant status 25 OH Vitamin D3 (ng/ml) Calcium (mg/dl) Phosphorus (mg/dl) Albumin (g/dl) Alkaline Phosphatase (IU/l) Fasting glucose (mg/dl) Lipid profile (mg/dl) Urea, creatinine (mg/dl) Blood pressure and ECG Timepoint: at baseline and after 8 weeks | — |
Countries
India
Contacts
Public ContactSURESH KUMAR S
JIPMER
Outcome results
None listed