Health Condition 1: null- Patients requiring esophagogastroduodenoscopy
Conditions
Interventions
Intervention1: propofol,ketamine: Ketamine (0.5mg/kg) by intravenous route.
Propofol(1mg/kg) by intravenous route will be given initially in aliquots of half dose(0.5 mg/kg)followed 15 seconds late
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: (1) Children 3 -12 years of age. (2) Patients requiring diagnostic/therapeutic EGD.
Exclusion criteria
Exclusion criteria: The children with the following features will be excluded from the study: (1) Allergy to the study drugs during earlier endoscopies/soya and egg allergy. (2) Documented difficulty to achieve sedation despite maximum admissible doses of these drugs during earlier sedation. (3) Hypertension /glaucoma. (4) Neuropsychiatric disorders/encephalopathy that impair assessment during recovery. (5) Difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: To compare the proportion of people who require additional doses of propofol in the first minute after sedation induction between the propofol - ketamine group and propofol - fentanyl group.Timepoint: Outcome assessed at the end of the study period. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the total additional doses of propofol needed in the first minute after sedation induction ,the total dose of propofol needed to achieve optimal sedation for performing esophagogastroduodenoscopy ,the frequency of the adverse effects occurring during period of sedation and recovery ,the need for reinsertion of the endoscope due to suboptimal sedation and the endoscopistâ??s satisfaction for the procedure when the two drug combinations are used. Timepoint: Outcome assessed at the end of the study period. | — |
Countries
India
Contacts
Public ContactJ Barath
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed