Health Condition 1: null- neonates with late onset sepsis
Conditions
Interventions
Intervention1: Antibiotic regimen: Cloxacillin + Amikacin were administered to 40 and Cefotaxime + Gentamicin to 50 babies.
Intervention2: Cloxacillin,Amikacin: Cloxacillin (100mg/kg/day)Intra Venous
Sponsors
Jawaharlal Institute of Post graduate Medical Education and Research JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Neonates born outside JIPMER within the age group of 3 to 28 days with evidence of LOS by both clinical and lab parameters were the target group. The clinical parameters used were poor feeding, poor activity, seizures, apnoea, respiratory distress, umbilical discharge and abdominal distension while the septic screen tests included micro erythrocyte sedimentation rate (mESR), C- reactive protein (CRP), absolute neutrophil count (ANC) and band cell count. Babies with atleast one of the above clinical parameters and two positive septic screen tests were included in the study.
Exclusion criteria
Exclusion criteria: Babies with major congenital anomalies, extreme prematurity ( <28 weeks), very low birth weight ( <1500 grams), congenital heart disease, severe asphyxia (5 minute Apgar <5) and babies who had received antibiotics prior to admission were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes were mortality prior to discharge from hospital, complications including shock, DIC, acidosis, renal failure and rehospitalisation within 2 weeks of discharge.Timepoint: within 2 weeks of discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment failure, subsequent fungal infections, duration of hospital stay, cost analysis and problems on follow up.Timepoint: 2 weeks and 1 month after discharge | — |
Countries
India
Contacts
Public ContactDR NIRANJAN BISWAL
Jawaharlal Institute of Post graduate Medical Education and Research (JIPMER)
Outcome results
None listed