COMPARING THE EFFECTIVENESS OF RAMOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING OCCURING AFTER AN OPERATION IN PATIENTS AT A HIGH RISK

INCIDENCE OF PONV: COMPARISION OF THE EFFICACY OF RAMOSETRON WITH ONDANSETRON IN THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING (PONV) IN HIGH RISK PATIENTS

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2013/02/003357

Enrollment

206

Registered

2013-02-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Adult Cancer patients undergoing cancer surgery and at a high risk for postoperative nausea and vomiting

Interventions

Intervention1: Ramosetron : Ramosetron - Dosage: 0.3 mg, single dose diluted to 4 ml with normal saline administered intravenously 30 minutes before the end of the surgery route Control Intervention

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients scheduled for breast surgery, parotid surgery, thyroid surgery, gynaecological surgeries. Aged between 20-60 years ASA physical status I or II At a high risk for PONV with at least 2 of the 4 risk factors mentioned below 1 Female patients 2 Non smoking status 3 Past h/o PONV or motion sickness 4 Postoperative opioid use

Exclusion criteria

Exclusion criteria: 1. Pregnant patient 2. Menstruating patients 3. History of GERD 4. Antemetic medication, nausea or vomiting prior to surgery 5. Major intraabdominal,thoracic, pelvic and reconstructive surgeries

Design outcomes

Primary

Measure	Time frame
The Incidence of post operative nausea and vomiting (PONV) during the first 24 h after an operationTimepoint: The first 24 h after an operation will be divided into three time intervals 0â??2 , 2â??6 and 6 -24 hours	—

Secondary

Measure	Time frame
The severity of nausea and The need for rescue medicationTimepoint: The first 24 h after an operation will be divided into three time intervals 0â??2 , 2â??6 and 6 -24 hours	—

Countries

India

Contacts

Public ContactDr Sandip Agarkar

Tata Memorial Hospital

aparnasanjay@hotmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026