Health Condition 1: null- Suspected or confirmed victims of cyanide poisoning
Conditions
Interventions
Intervention1: Sodium Alpha-ketoglutarate (AKG) nebulization fluid along with Injection Sodium thiosulphate: 25% sodium AKG respiratory solution in 20% ethanol. 3 ml to be inhaled through nebulization
Sponsors
Defence Research and Development Organisation
Eligibility
Inclusion criteria
Inclusion criteria: a) Rescue workers just before entry in areas of fire, smoke, fumes(particularly where plastic is burning), environments containing hydrogen cyanide/ MIC/ ammonia gas; b) Suspected or confirmed victims of the above with moderate-to-severe symptoms while they are leaving the contaminated zone
Exclusion criteria
Exclusion criteria: a)Where conventional medical treatment is available and the medical team decides in favor of conventional treatment alone or no treatment at all; b)Where the team leader / participants rescue workers are unwilling to take the prophylaxis before entering the danger zones, or refusal by exposed patients to undertake the therapy; c)Subjects / Patients having any contraindications like severe breathlessness, unstable cardiac rhythm, tachycardia etc.; d)Subjects / Patients who have compromised lung function due to any cause; e)Patients who have any medical condition which in the judgment of the investigator may render them inappropriate for participation in the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in mortality and severity of morbidity attributable to hydrogen cyanide /MIC /ammonia gasTimepoint: At the discretion of treating physician at site of accident/ disaster with the primary aim of reversal of clinical effects of cyanide/ MIC/ ammonia gas poisoning in patients receiving combination therapy consisting of AKG inhalation with conventional treatment in comparison to those receiving only conventional or no treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in hydrogen cyanide /MIC /ammonia gas induced toxicity symptoms with respect to parameters mentioned below:Timepoint: a)Level of consciousness; b)Level of vital signs; c)Reversal of level of dypnoea; d)Number of lives saved (independently or as part of larger therapy); e)Comparison of signs & symptoms (blood oxygen or cyanide levels wherever possible) with subjects receiving similar amount of the poisonous inhalation but not receiving the antidote or receiving some other emergency therapy; f)Amelioration of local respiratory effects of the cyanide poisoning / MIC / ammonia gas | — |
Countries
India
Contacts
Public ContactAseem Bhatnagar
Defence Research and Development Organisation
Outcome results
None listed