Health Condition 1: null- Cyanide poisoning
Conditions
Interventions
Intervention1: Injection Sodium alpha-ketoglutarate (AKG) in combination with Injection sodium thiosulphate (STS): Single dose treatment with 20 ml of 12.5% solution of sodium alpha-ketoglutarate inje
Sponsors
Defence Research and Development Organisation
Eligibility
Inclusion criteria
Inclusion criteria: a) Suspected or confirmed victims of cyanide poisoning (isolated or mass casualties) b) Suspected or confirmed victims of fire smoke / attack / act of terrorism with moderate-to-severe symptoms, including comatose subjects c) Rescue workers exposed to suspected to have been exposed to cyanide gas d) Very sick / comatose / non-respondent patients can also be taken up e) Pregnancy no bar in very sick patients confirmed as having likely to be lethal cyanide poisoning f) Subjects where conventional anticyanide treatment has been given, or is being given concurrently, or will be given later on
Exclusion criteria
Exclusion criteria: a) Those suffering from any disease or taking any treatment interfering with the AKG levels or cyanide levels in blood b)Any medical / social condition which in view of the investigators is deleterious for the subject / successful conduction of the test c) Where conventional medical treatment is available and the medical team decides in favor of conventional treatment alone d) Patients having any contraindications like severe diabetes mellitus, renal disease, severe blood pressure abnormality e) Refusal by patients / relatives (in case the patient is a minor or is in coma) f) Patients who have any medical condition which in the judgment of the investigator may render them in appropriate for participation in the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in mortality and severity of morbidity attributable to cyanide poisoningTimepoint: At the discretion of treating physician at the site of accident with the primary aim of reversal of clinical effects of cyanide poisoning in patients receiving AKG â?? thiosulphate combination therapy in comparison to those who received thiosulphate alone. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in cyanide induced toxicity symptoms with respect to parameters mentioned below:Timepoint: At the discretion of the treating physician at the field level. | — |
Countries
India
Contacts
Public ContactAseem Bhatnagar
Defence Research and Development Organisation
Outcome results
None listed