Health Condition 1: null- Severe hypertension during pregnancy
Conditions
Interventions
Intervention1: intravenous labetalol: Intravenous Labetalol
20, 40, 80, 80, 80 at 20 minutes interval with maximum of 300 mg
Control Intervention1: Oral Nifedipine: Oral Nifedipine
10 mg at 20 minut
Sponsors
Institutional
Eligibility
Inclusion criteria
Inclusion criteria: • Age 18 â?? 45 years • Period of gestation >= 24 weeks • Blood pressure : Systolic >= 160 mm of Hg or Diastolic >= 110 mm Hg • Maternal heart rate >=60 bpm and • Reassuring fetal heart rate
Exclusion criteria
Exclusion criteria: • History of heart rhythm abnormality • History of heart failure • History of bronchial asthma • History of allergy to either nifedipine or labetalol • Non pregnancy related hypertension • Any hypertensive treatment in preceding 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken to achieve the target systolic BP of â?¤ 150 mm of Hg and diastolic BP of â?¤ 100 mm of Hg ( both targets have to be fulfilled)Timepoint: Minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ Total number of antihypertensive dosages required to achieve the target systolic BP of â?¤ 150 mm of Hg and diastolic BP of â?¤ 100 mm of Hg ( both targets have to be fulfilled) â?¢ Maternal heart rate profile during the first 80 minutes â?¢ Maternal hypotension (BP 90/60 mm of Hg) â?¢ Side effects profile â?¢ Perinatal outcomeTimepoint: Number of dosages ( 1-5) | — |
Countries
India
Contacts
Public ContactDr Shashank Shekhar
Dr RPGMC Tanda
Outcome results
None listed