Health Condition 1: null- Suspected or confirmed victims of cyanide poisoning/ terrorism, or Rescue workers exposed to or suspected to have been exposed to cyanide, including hydrogen cyanide
Conditions
Interventions
Intervention1: Disodium alpha-ketoglutarate: Disodium alpha-ketoglutarate 20 grams dispensed as powder in 5/10 gram sachets to be taken orally with water or as preformed solution to be drunk from a bo
Sponsors
Defence Research and Development Organisation
Eligibility
Inclusion criteria
Inclusion criteria: The study shall include: a) Suspected or confirmed victims of isolated cyanide poisoning; b) Suspected or confirmed victims of cyanide terrorism; c) Rescue workers exposed to or suspected to have been exposed to cyanide, including hydrogen cyanide
Exclusion criteria
Exclusion criteria: Following human subjects will be excluded from the study: a) Uncontrolled vomiting b) Altered sensorium where oral administration is impossible and Ryles intubation not available c)Where conventional medical treatment is available and the medical team decides in favor of conventional treatment only. d) Subject / caretaker refusal (in case of patient being in Coma) e) Patients who have any medical condition which in the judgment of the investigator may render them inappropriate for participation in the trial
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Reduction in cyanide induced toxicity symptoms with respect to parameters mentioned below:Timepoint: a) Level of consciousness b) Reversal of respiratory distress c) Betterment of arousal state d) Comparison between amount of life-support or supportive care needed at hospital in the two groups | — |
Primary
| Measure | Time frame |
|---|---|
| Reduction in mortality and severity of morbidity due to cyanide poisoningTimepoint: Reduction in mortality and severity of morbidity due to cyanide poisoning | — |
Countries
India
Contacts
Public ContactAseem Bhatnagar
Defence Research and Development Organisation
Outcome results
None listed