Health Condition 1: null- for short surgical procedures
Conditions
Interventions
Control Intervention1: INJ PROPOFOL: 2.5 MG/KG INTRAVENOUSLY FOR INDUCTION
Control Intervention2: INJ THIOPENTONE SODIUM: 5 MG/KG INTRAVENOUSLY FOR INDUCTION
Control Intervention3: INJ ETOMIDATE: 0.3
Sponsors
nil
Eligibility
Inclusion criteria
Inclusion criteria: This study was conducted on 60 patients of either sex in the age range of 16 to 60 years and belonging to American Society of Anesthesiologists(ASA) grade 1/2.Prior approval of the Instituteâ??s medical ethics committee was obtained. Informed written consent was taken from all the patients.
Exclusion criteria
Exclusion criteria: The patients with known history of allergy to these drugs, hemodyna-mically unstable patients and unwilling/uncooperative patients with psychiatric illness were excluded from the study so also patients on drug therapy known to interfere with pharmacokinetics of these anesthetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Etomidate was found to be the most rapidly acting induction agent among the three agents. This difference was statistically highly significant(P0.0001). The difference in onset of action between Thiopental and Propofol was clinically and statistically not significant.(Timepoint: Onset of action(induction time) for propofol was 20.15+-2.01sec,for thiopental 23.9+-1.41sec and for Etomidate it was 13.4+-1.63sec. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of pain on iv injection and respiratory depression was seen with Propofol. No major side effects were seen with Thiopental. Myoclonic limb movements and PONV was observed with Etomidate.Timepoint: Onset of action (induction time) was shortest with Etomidate followed by propofol and then thiopental;VAS in the three groups during 2 hours postoperatively did not show any significant difference.Timepoint: Mean VAS was 0 in thiopental and Propofol group and 0.1+-0.45 in Etomidate group. | — |
Countries
India
Contacts
Public ContactDr Piyush Setu
Pad. Dr. D.Y. Patil medical college
Outcome results
None listed