Health Condition 1: null- Head and Neck Squamous Cell Carcinoma
Conditions
Interventions
Intervention1: Radiotherapy with carotid sparing: Using Helical tomotherapy - treating to a dose of 55Gy in 20 fractions, also sparing of carotid artery to be done during planning process.(Overall ti
Sponsors
Tata Medical Center Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: Tomotherapy group ALL of: Adult patients Squamous Cell CA of the glottis Suited to have radical radiotherapy Who gives informed consent T1 or T2 tumour of the Glottis No neck nodal involvement Suited to receive 55Gy in 20 fractions Control group: Any patient needing radiotherapy without carotid sparing, to the neck
Exclusion criteria
Exclusion criteria: Any of the above criteria not met Previous Radiotherapy to head or neck Known carotid arterial disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Endpoint: Feasibility of clinical implementation of image guided Tomotherapy The percentage change in the intimal thickness following radiotherapy The percentage difference in mean % carotid artery intimal thickness following radiotherapy in the two groups Timepoint: pre treatment, 6m, and 18 months post treatment for carotid scans 1 year for accrual | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify if maximum dose to the carotids would predict changes on Doppler as opposed to higher (35Gy) median or mean dose To identify if carotid Doppler at 6 months could predict longer term changes in carotid intimal thickness Timepoint: 6months and 18 months post radiotherapy | — |
Countries
India
Contacts
Public ContactDr Sanjoy Chatterjee
Outcome results
None listed