Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for sedation in children undergoing MRI.

Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI; a double blind, randomized, placebo controlled trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2012/11/003146

Enrollment

135

Registered

2012-11-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Children 1-10 years of age undergoing elective, diagnostic magnetic resonance imaging (MRI)

Interventions

Intervention1: Dexmedetomidine: 1mcg/kg, single dose, intranasally, 1 hour before procedure Intervention2: Ketamine: 5mg/kg, single dose, intranasally, 30 minutes before Control Intervention1: Plain s

Eligibility

Inclusion criteria

Inclusion criteria: Undergoing elective magnetic resonance imaging (MRI) under sedation

Exclusion criteria

Exclusion criteria: a) consent not given b) allergy to dexmedetomidine or ketamine c) expected difficult airway d) heart or lung disease e) emergency procedure

Design outcomes

Primary

Measure	Time frame
Ease of intravenous cannulationTimepoint: When hands are held When approached with needle When skin is puncture	—

Secondary

Measure	Time frame
Anaesthesiologists, parents and radiologists satisfactionTimepoint: End of procedure;Childs acceptance of intranasal drugsTimepoint: when premedication is administered;Dose of propofol requiredTimepoint: End of procedure;incidence of side effectTimepoint: throughout the procedure and uptill 3 hours after the end of procedure;Time to awakening and fitness to dischargeTimepoint: End of procedure	—

Countries

India

Contacts

Public ContactPrakhar Gyanesh

Sanjay Gandhi Postgraduate Institute, Lucknow

pksingh@sgpgi.ac.in08004904587

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026