Health Condition 1: null- High grade Glioma
Conditions
Interventions
Intervention1: Hypofractionated Radiation therapy: After informed consent, baseline study assessments will be done including detailed clinical/neurological assessment, performance status assessment, a
Sponsors
Tata Memorial Centre Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Poor-prognosis HGG defined as a] Patient aged >18 but =3 b] Patients aged >50 but =2 c] Patients over >65 years of age with KPS =1 2. Histo-pathologically proven HGG including variants 3. Available pre-surgical imaging (CT/MRI) 4. Written informed consent from patient/care- giver 5. Adjuvant therapy starting within 6 weeks (preferably within 4 weeks) of surgery 6. Life-expectancy of at least 3 months
Exclusion criteria
Exclusion criteria: 1 Children 18 years of age 2 Patients deemed suitable for conventionally fractionated radiotherapy 3 Unconfirmed histology 4 Recurrent/progressive disease or transformed HGG from previous low-grade glioma 5 Carmustine wafers implanted at surgery 6 Pregnancy or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compliance to continuous short-course hypofractionated radiation therapyTimepoint: Two weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| a] Median survival in months, 6-month overall survival, and 1-year overall survival b] Change in QOL scores serially longitudinally over time Timepoint: 6 months to 1 year | — |
Countries
India
Contacts
Public ContactDr Tejpal Gupta
Tata Memorial Centre Tata Memorial Hospital and ACTREC
Outcome results
None listed