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Root canal treatment without obturation with regenerative technique

A randomized equivalence clinical trial to evaluate the efficacy of an innovative, non-obturation endodontic treatment protocol â??SealBioâ?? for mature, permanent non-vital teeth as compared to conventional endodontic treatment with root canal obturation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/11/003102
Enrollment
192
Registered
2012-11-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Periapical pathologies associated with infected, non-vital mature, permanent teeth

Interventions

Intervention1: Innovative non-obturation Endodontic technique: After control of intra canal infection by chemo-mechanical means, indigenous stem cells residing in the periapical area of teeth being tr

Sponsors

Indian Council of Medical Research ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cases presenting with clinical or radiographic signs and symptoms of periapical pathologies, irrespective of age and sex will be included in the study

Exclusion criteria

Exclusion criteria: Patients having any systemic disease, which can compromise the healing response such as diabetes, patients on excessive medications, on immuno-suppressants, those receiving RT or CT etc. will not be included

Design outcomes

Primary

MeasureTime frame
Complete control and resolution of clinical signs and symptoms of periapical disease, such as pain, swelling, inflammation and restoration of function Radiographic evidence of healing of periapical lesions showing disappearance or reduction in size of the lesion or atleast arrest of lesion size (not increasing)Timepoint: followed up at 3, 6 months, 1, 1 ½ and 2 years

Secondary

MeasureTime frame
Formation of a natural, biological seal of mineralized tissue at the root apicesTimepoint: followed up at 3, 6 months, 1, 1 ½ and 2 years

Countries

India

Contacts

Public ContactDr Naseem Shah

Centre for dental education and research

naseemys@gmail.com26589304

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026