Health Condition 1: null- Patients with Isolated, Closed and Gustilo Anderson type I open proximal 2/3rd tibia fractures (Intracompartmental pressure in the leg are measured in these patients).
Conditions
Interventions
Intervention1: Intracompartmental pressure measurement: Intracompartmental pressure is measured before giving and 1 and 3 hours after giving the agents by stryker hand held pressure monitor.
Control I
Sponsors
Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: All patients presenting to emergency department with isolated acute, closed and Gustilo Anderson type I open, proximal 2/3rd tibia fracture.
Exclusion criteria
Exclusion criteria: Patients with contraindication to mannitol are excluded (heart failure, pulmonary congestion, hypotension, anuria, liver failure, intracranial bleed) .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The mean reduction in the compartment pressures in normal saline group and mannitol group. This will be measured 1 hr and 3 hours after giving the study and comparator drug. It will be measured by Dr. N. Jerry in all patients. 2. The number of patients in whom compartment syndrome develops. This is based on the clinical criteria.Timepoint: Pressures are measured before giving the agents and 1 and 3 hours after administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effect profile of mannitol drug.Timepoint: Number developing renal failure in mannitol group. | — |
Countries
India
Contacts
Public ContactDr Thilak
Christian Medical College Hospital
Outcome results
None listed